2021
Evaluating Outcomes Related to Donor and Recipient Metabolic Environment: Macrosteatotic Allografts and Nonalcoholic Steatohepatitis.
Altshuler PJ, Dang H, Frank AM, Shah AP, Glorioso J, Zhan T, Rios Diaz A, Shaheen O, Ramirez CB, Maley WR, Bodzin AS. Liver Transpl. 2021 Sep 26;. doi: 10.1002/lt.26313. [Epub ahead of print] PubMed PMID: 34564931.
Tumor metabolism and associated serum metabolites define prognostic subtypes of Asian hepatocellular carcinoma.
Pomyen Y, Budhu A, Chaisaingmongkol J, Forgues M, Dang H, Ruchirawat M, Mahidol C, Wang XW. Sci Rep. 2021 Jun 8;11(1):12097. doi: 10.1038/s41598-021-91560-1. PubMed PMID: 34103600; PubMed Central PMCID: PMC8187378.
Simultaneous liver kidney allocation policy and the Safety Net: an early examination of utilization and outcomes in the United States.
Altshuler PJ, Shah AP, Frank AM, Glorioso J, Dang H, Shaheen O, Patel K, Ramirez CB, Maley WR, Bodzin AS. Transpl Int. 2021 Apr 21;. doi: 10.1111/tri.13891. [Epub ahead of print] PubMed PMID: 33884677.
Intratumoral γδ T-Cell Infiltrates, Chemokine (C-C Motif) Ligand 4/Chemokine (C-C Motif) Ligand 5 Protein Expression and Survival in Patients With Hepatocellular Carcinoma.
Zhao N, Dang H, Ma L, Martin SP, Forgues M, Ylaya K, Hewitt SM, Wang XW. Hepatology. 2021 Mar;73(3):1045-1060. doi: 10.1002/hep.31412. PubMed PMID: 32502310.
2020
Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers. Clin Cancer Res.
Høgdall D, O'Rourke CJ, Dehlendorff C, Larsen OF, Jensen LH, Johansen AZ, Dang H, Factor VM, Grunnet M, Mau-Sørensen M, Oliveira DVNP, Linnemann D, Boisen MK, Wang XW, Johansen JS, Andersen JB. 2020 Nov 1;26(21):5655-5667. doi: 10.1158/1078-0432.CCR-19-2700. Epub 2020 Sep 15. PubMed PMID: 32933994.
Hepatocellular Carcinoma-The Influence of Immunoanatomy and the Role of Immunotherapy.
Patel K, Lamm R, Altshuler P, Dang H, Shah AP. Int J Mol Sci. 2020 Sep 15;21(18). doi: 10.3390/ijms21186757. Review. PubMed PMID: 32942580; PubMed Central PMCID: PMC7555667.
Hepatic Stellate Cells and Hepatocarcinogenesis.
Barry AE, Baldeosingh R, Lamm R, Patel K, Zhang K, Dominguez DA, Kirton KJ, Shah AP, Dang H. Front Cell Dev Biol. 2020;8:709. doi: 10.3389/fcell.2020.00709. eCollection 2020. Review. PubMed PMID: 32850829; PubMed Central PMCID: PMC7419619.
PKM2 inhibition may reverse therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma.
Martin SP, Fako V, Dang H, Dominguez DA, Khatib S, Ma L, Wang H, Zheng W, Wang XW. J Exp Clin Cancer Res. 2020 Jun 3;39(1):99. doi: 10.1186/s13046-020-01605-y. PubMed PMID: 32487192; PubMed Central PMCID: PMC7268641.
AGO2 Mediates MYC mRNA Stability in Hepatocellular Carcinoma.
Zhang K, Pomyen Y, Barry AE, Martin SP, Khatib S, Knight L, Forgues M, Dominguez DA, Parhar R, Shah AP, Bodzin AS, Wang XW, Dang H. Mol Cancer Res. 2020 Apr;18(4):612-622. doi: 10.1158/1541-7786.MCR-19-0805. Epub 2020 Jan 15. PubMed PMID: 31941754; PubMed Central PMCID: PMC7127970.
Understanding the Cause and Consequence of Tumor Heterogeneity.
Khatib S, Pomyen Y, Dang H, Wang XW. Trends Cancer. 2020 Apr;6(4):267-271. doi: 10.1016/j.trecan.2020.01.010. Epub 2020 Feb 13. PubMed PMID: 32209440.
Depletion of TRRAP Induces p53-Independent Senescence in Liver Cancer by Down-Regulating Mitotic Genes.
Kwan SY, Sheel A, Song CQ, Zhang XO, Jiang T, Dang H, Cao Y, Ozata DM, Mou H, Yin H, Weng Z, Wang XW, Xue W. Hepatology. 2020 Jan;71(1):275-290. doi: 10.1002/hep.30807. Epub 2019 Aug 11. PubMed PMID: 31188495; PubMed Central PMCID: PMC6906267.
2019
Functional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer.
Kwon SM, Budhu A, Woo HG, Chaisaingmongkol J, Dang H, Forgues M, Harris CC, Zhang G, Auslander N, Ruppin E, Mahidol C, Ruchirawat M, Wang XW. Sci Rep. 2019 Nov 15;9(1):16930. doi: 10.1038/s41598-019-52578-8. PubMed PMID: 31729408; PubMed Central PMCID: PMC6858353.
Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM+ Hepatocellular Carcinoma.
Takai A, Dang H, Oishi N, Khatib S, Martin SP, Dominguez DA, Luo J, Bagni R, Wu X, Powell K, Ye QH, Jia HL, Qin LX, Chen J, Mitchell GA, Luo X, Thorgeirsson SS, Wang XW. Cancer Res. 2019 May 1;79(9):2379-2391. doi: 10.1158/0008-5472.CAN-18-3015. Epub 2019 Mar 12. PubMed PMID: 30862714; PubMed Central PMCID: PMC6497533.
NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma.
Dang H, Pomyen Y, Martin SP, Dominguez DA, Yim SY, Lee JS, Budhu A, Shah AP, Bodzin AS, Wang XW. Sci Rep. 2019 Mar 4;9(1):3369. doi: 10.1038/s41598-019-39727-9. PubMed PMID: 30833661; PubMed Central PMCID: PMC6399236.
2018
Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis.
Zhu K, Tang Y, Xu X, Dang H, Tang LY, Wang X, Wang XW, Zhang YE. PLoS Biol. 2018 Dec;16(12):e3000091. doi: 10.1371/journal.pbio.3000091. eCollection 2018 Dec. PubMed PMID: 30566427; PubMed Central PMCID: PMC6317813.
Necroptosis microenvironment directs lineage commitment in liver cancer.
Seehawer M, Heinzmann F, D'Artista L, Harbig J, Roux PF, Hoenicke L, Dang H, Klotz S, Robinson L, Doré G, Rozenblum N, Kang TW, Chawla R, Buch T, Vucur M, Roth M, Zuber J, Luedde T, Sipos B, Longerich T, Heikenwälder M, Wang XW, Bischof O, Zender L. Nature. 2018 Oct;562(7725):69-75. doi: 10.1038/s41586-018-0519-y. Epub 2018 Sep 12. PubMed PMID: 30209397; PubMed Central PMCID: PMC8111790.
Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma.
Zheng H, Pomyen Y, Hernandez MO, Li C, Livak F, Tang W, Dang H, Greten TF, Davis JL, Zhao Y, Mehta M, Levin Y, Shetty J, Tran B, Budhu A, Wang XW. Hepatology. 2018 Jul;68(1):127-140. doi: 10.1002/hep.29778. Epub 2018 May 9. PubMed PMID: 29315726; PubMed Central PMCID: PMC6033650.
The significance of intertumor and intratumor heterogeneity in liver cancer.
Liu J, Dang H, Wang XW. Exp Mol Med. 2018 Jan 5;50(1):e416. doi: 10.1038/emm.2017.165. Review. PubMed PMID: 29303512; PubMed Central PMCID: PMC5992990.
2017
Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth.
Liu J, Kruswick A, Dang H, Tran AD, Kwon SM, Wang XW, Oberdoerffer P. Nat Commun. 2017 Jul 26;8(1):137. doi: 10.1038/s41467-017-00206-2. PubMed PMID: 28743957; PubMed Central PMCID: PMC5526993.
Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma.
Dang H, Takai A, Forgues M, Pomyen Y, Mou H, Xue W, Ray D, Ha KCH, Morris QD, Hughes TR, Wang XW. Cancer Cell. 2017 Jul 10;32(1):101-114.e8. doi: 10.1016/j.ccell.2017.06.002. PubMed PMID: 28697339; PubMed Central PMCID: PMC5539779.
Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma.
Chaisaingmongkol J, Budhu A, Dang H, Rabibhadana S, Pupacdi B, Kwon SM, Forgues M, Pomyen Y, Bhudhisawasdi V, Lertprasertsuke N, Chotirosniramit A, Pairojkul C, Auewarakul CU, Sricharunrat T, Phornphutkul K, Sangrajrang S, Cam M, He P, Hewitt SM, Ylaya K, Wu X, Andersen JB, Thorgeirsson SS, Waterfall JJ, Zhu YJ, Walling J, Stevenson HS, Edelman D, Meltzer PS, Loffredo CA, Hama N, Shibata T, Wiltrout RH, Harris CC, Mahidol C, Ruchirawat M, Wang XW. Cancer Cell. 2017 Jul 10;32(1):57-70.e3. doi: 10.1016/j.ccell.2017.05.009. Epub 2017 Jun 22. PubMed PMID: 28648284; PubMed Central PMCID: PMC5524207.
Cancer exosomes: wanted by many, explored by few, waiting for one.
Dang H, Zhao X, Chow CW. Ann Transl Med. 2017 May;5(10):220. doi: 10.21037/atm.2017.02.21. PubMed PMID: 28603735; PubMed Central PMCID: PMC5451620.
2016
LTβR signalling preferentially accelerates oncogenic AKT-initiated liver tumours.
Scarzello AJ, Jiang Q, Back T, Dang H, Hodge D, Hanson C, Subleski J, Weiss JM, Stauffer JK, Chaisaingmongkol J, Rabibhadana S, Ruchirawat M, Ortaldo J, Wang XW, Norris PS, Ware CF, Wiltrout RH. Gut. 2016 Oct;65(10):1765-75. doi: 10.1136/gutjnl-2014-308810. Epub 2015 Jul 23. PubMed PMID: 26206664; PubMed Central PMCID: PMC5036232.
Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma.
Takai A, Fako V, Dang H, Forgues M, Yu Z, Budhu A, Wang XW. Sci Rep. 2016 Feb 16;6:21174. doi: 10.1038/srep21174. PubMed PMID: 26880118; PubMed Central PMCID: PMC4754778.
2015
Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma.
Ji J, Eggert T, Budhu A, Forgues M, Takai A, Dang H, Ye Q, Lee JS, Kim JH, Greten TF, Wang XW. Hepatology. 2015 Aug;62(2):481-95. doi: 10.1002/hep.27822. Epub 2015 Apr 28. PubMed PMID: 25833323; PubMed Central PMCID: PMC4515211.
The EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met+ Hepatocellular Carcinoma.
Steinway SN, Dang H, You H, Rountree CB, Ding W. PLoS One. 2015;10(5):e0128159. doi: 10.1371/journal.pone.0128159. eCollection 2015. PubMed PMID: 26000702; PubMed Central PMCID: PMC4441360.
Induction of tumor initiation is dependent on CD44s in c-Met⁺ hepatocellular carcinoma.
Dang H, Steinway SN, Ding W, Rountree CB. BMC Cancer. 2015 Mar 21;15:161. doi: 10.1186/s12885-015-1166-4. PubMed PMID: 25886575; PubMed Central PMCID: PMC4380258.
2014
Identification of drivers from cancer genome diversity in hepatocellular carcinoma.
Takai A, Dang HT, Wang XW. Int J Mol Sci. 2014 Jun 20;15(6):11142-60. doi: 10.3390/ijms150611142. Review. PubMed PMID: 24955791; PubMed Central PMCID: PMC4100204.
The origin of cancer stem cells.
Dang HT, Budhu A, Wang XW. J Hepatol. 2014 Jun;60(6):1304-5. doi: 10.1016/j.jhep.2014.03.001. Epub 2014 Mar 13. PubMed PMID: 24631602.
2012
miR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma.
Ding W, Dang H, You H, Steinway S, Takahashi Y, Wang HG, Liao J, Stiles B, Albert R, Rountree CB. Oncogenesis. 2012 Jun 11;1:e15. doi: 10.1038/oncsis.2012.15. PubMed PMID: 23552699; PubMed Central PMCID: PMC3412647.
2011
Isolation of CD133+ liver stem cells for clonal expansion.
Rountree CB, Ding W, Dang H, Vankirk C, Crooks GM. J Vis Exp. 2011 Oct 10;(56). doi: 10.3791/3183. PubMed PMID: 22006186; PubMed Central PMCID: PMC3227180.
Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics.
Dang H, Ding W, Emerson D, Rountree CB. BMC Cancer. 2011 Sep 19;11:396. doi: 10.1186/1471-2407-11-396. PubMed PMID: 21929801; PubMed Central PMCID: PMC3189192.
c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma.
You H, Ding W, Dang H, Jiang Y, Rountree CB. Hepatology. 2011 Sep 2;54(3):879-89. doi: 10.1002/hep.24450. Epub 2011 Jul 19. PubMed PMID: 21618573; PubMed Central PMCID: PMC3181384.
2010
Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.
Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles BL. Gastroenterology. 2010 Dec;139(6):2170-82. doi: 10.1053/j.gastro.2010.09.002. Epub 2010 Sep 15. PubMed PMID: 20837017; PubMed Central PMCID: PMC2997180.
Clinical application for the preservation of phospho-proteins through in-situ tissue stabilization.
Rountree CB, Van Kirk CA, You H, Ding W, Dang H, VanGuilder HD, Freeman WM. Proteome Sci. 2010 Nov 22;8:61. doi: 10.1186/1477-5956-8-61. PubMed PMID: 21092202; PubMed Central PMCID: PMC3000382.
Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion.
Ding W, You H, Dang H, LeBlanc F, Galicia V, Lu SC, Stiles B, Rountree CB. Hepatology. 2010 Sep;52(3):945-53. doi: 10.1002/hep.23748. PubMed PMID: 20564331; PubMed Central PMCID: PMC3032356.
2008
SALL4 is a key regulator of survival and apoptosis in human leukemic cells.
Yang J, Chai L, Gao C, Fowles TC, Alipio Z, Dang H, Xu D, Fink LM, Ward DC, Ma Y. Blood. 2008 Aug 1;112(3):805-13. doi: 10.1182/blood-2007-11-126326. Epub 2008 May 16. PubMed PMID: 18487508; PubMed Central PMCID: PMC2481537.